Ernest Hemingway Essay

Introduction To be a writer you must need to be passion, but most important feel the passion for what you do. It’s not something that grows in one day. Ernest Hemingway and Russell Banks were dedicated writer who enjoyed writing. They both wrote about true stories where the readers will feel identify by the story. Proposal Ernest Hemingway and Russell Banks both wrote about abortion, but in huge different style. As author they have different style in write, and different way to think. In one hand we have Ernest Hemingway with â€Å"Hill like White Elephants†. In this story the theme is abortion, but you have to be carefully to identify the theme, because it is kind of confuse about what the couple were talking; the story seems like if the author was tried to hind it. Hemingway’s typical style is a dialogue between characters; it is continuo he used signal phrase placements in his stories. Also Hemingway used a descriptive language as example: â€Å"the girl stood up and walked to the end of the station. Across, on the other side, were fields of grain and trees along the banks of the Ebro†(275). On the other hand we have Russell Banks with â€Å"Black Man and White Woman in Dark Green Rowboat†. He also wrote about abortion, but he tried to put it a little bit more dramatic; including racism between the couple who were one black and one white. Russell used a more narrative style in his stories, and less dialogue the readers can see dialogue when the story is unfolds contrary to Hemingway. However Russell used more descriptive language. He emphasized in every detail about the story in the landscape, and in the same way for characters. Russell descriptive by used color as example: â€Å"by the time he closed his door the water was smooth again, dark green plain beneath the thick gray-blue sky†(1). Conclusion Each author have a different way to write that’s make them unique and distinct from each other, but in most cases authors used the same theme but in different ways and based in they own experiences.

Jewish Celebrations

Jewish Celebrations – Individual Questions 39†² blue]0111eranchers103 A. Briefly explain the significance of your celebration (historical events/key themes) Yom HaShoah, Or Holocaust Remembrance Day, iS a very important Jewish Holiday. IVS their day Of morning the victims and reflecting on the events that took place during the holocaust (January 30, 1933 – May 8, 1945). Yom HaShoah gives them a chance to get together as a community or With their families to remember and pay respect to the 6 000 000 Jews Who died. Mourning, respect, and remembrance are defiantly the key themes to this day. B.Identify the time of year It is celebrated, plus the symbols and/or foods used during the celebrations? Yom HaShoah takes place on the 27th of the month of Nisan (March/April) and lasts only 1 day. Unless the 27th would be adjacent to Shabbat, n which case the date s shifted by a day. It marks the anniversary at the Warsaw Ghetto uprising. Since t's a relatively new holiday ther e arent actually that many ntuals or symbols. The only one I could find that was a symbol is the 6 candles that Jews light In their homes and in the synagogues that represent the six million Jews who were killed during the holocaust.Radio stations feature recitation of appropriate songs and readings. television stations play Holocaustthemed films or a program featuring Holocaust survivors sharing their stories. C. Read the scriptural passage that is related to your topic. Explain how the celebration is connected to the scriptural passage. Each synagogue celebrates it a little differently. It's common that the Kaddish (on attached page) is recited, which is a prayer for the departed. Yom HaShoah is Remembrance Day of the holocaust, which is why the Kaddish is completely fitting. In recent years a new literary scroll has been created.This scroll iS called ‘Megillat Hashoah† (The Holocaust Scroll) created by the Conservative movement as a joint project Of rabbis and lay-lea ders in Canada, the u. S. , and Israel. This Holocaust scroll contains personal recollections Of Holocaust survivors and iS written in biblical style. It'S becoming more common for this scroll to be read ‘n a ritual style on Vorn Hashoah_ some ceriornonies have people read from the book of names for certain lengths of time to give understanding of the huge numbers of victims. D. Why do you think it Is important for people to celebrate their past?In the sense of this holiday for Jewish people I think it's Important to celebrate their past to remember all they have lost. and to be proud of all they have over come. Its also important to remember and celebrate their loved ones and the heroism ot there people. People must look back and learn about all aspect of history, good and bad, to ensure that the bad dont repeat ever again. By blueJollieranchers103 Yom Hashoah, or Holocaust Remembrance Day, is a very important Jewish Holiday. It's their day of morning the victims and reflecti ng on the events that took place uring the holocaust Oanuary 30, 1933 – May 8, 1945).Yom Hashoah gives them a chance to get together as a community or with their families to remember and pay respect to the 6 000 000 Jews who died. Mourning, respect, and remembrance are B. Identify the time of year it is celebrated, plus the symbols and/or foods used Yom Hashoah takes place on the 27th of the month of Nisan (March/April) and lasts only 1 day. Unless the 27th would be adjacent to Shabbat, in which case the date is shifted by a day. It marks the anniversary of the Warsaw Ghetto uprising. Since it's a relatively new holiday there aren't actually that many rituals or symbols.The only one I could find that was a symbol is the 6 candles that Jews light in their readings, television stations play Holocaust-themed films or a program featuring attached page) is recited, which is a prayer for the departed. Yom Hashoah is recent years a new literary scroll has been created. This scroll i s called â€Å"Megillat Hashoah† (The Holocaust Scroll) created by the Conservative movement as a Joint project of rabbis and lay-leaders in Canada, the U. S. , and Israel. This Holocaust scroll ontains personal recollections of Holocaust survivors and is written in biblical style.It's becoming more common for this scroll to be read in a ritual style on Yom Hashoah. Some Ceriomonies have people read from the book of names for certain D. Why do you think it is important for people to celebrate their past? In the sense of this holiday for Jewish people I think it's important to celebrate their past to remember all they have lost, and to be proud of all they have over come. It's also important to remember and celebrate their loved ones and the heroism of bad, to ensure that the bad don't repeat ever again.

The surface below Ai's handcuff Essay Example | Topics and Well Written Essays - 750 words

The surface below Ai's handcuff - Essay Example The â€Å"Jade Handcuffs† represents superb creativity and aesthetic taste of Ai, but more significantly, it is a powerful indictment to the injustice imposed on him by the government that suppresses liberty and democracy. The complex issues behind the simple-looking craftwork are noteworthy and deserve to be reflected upon. Ai Weiwei was born in 1957, Beijing. He is always recognized as a reputable artist who has been crafting a variety of art works throughout his career and also a cultural arbiter in terms of his heavy condemnation of the Chinese Communist Party by the public media. â€Å"The Jade handcuffs† is fairly small in scale, has nine serrates, and it was carved out from black Jade stone. According to Lisson gallery, this art piece was initially sold for 70,000 Euros in 2013 and subsequently made its debut in Ai’s first retrospective show: According To What? This craftwork signifies Ai’s 81 days in detention by Chinese government in 2011. After his release, he used the exact image of the handcuff used on him in jail to create this piece which was carved from jade stone which is a precious Chinese material that is often used as family heirlooms in ancient China. Jade is also a symbolic stone because it is used to represent and reminiscent of the prosperous and China’ s imperial past. The sublime quality of black jade gives the artwork a warm smooth touch. His brilliant choice of medium recalls an ancient artistic heritage while at the same time referring to the repressive nature of the current political system.2 Regardless of the simple appearance of Ai’s handcuff, the craftsmanship involved in its production is quiet complicated. Ai worked with a highly skillful carver while making his handcuffs. The carvers’ skill is particularly evident in the interlocking rings that form the chain, which were neither joined nor glued, but rather cut of the same single

Essay applying theories of political economy to music

Applying theories of political economy to music - Essay Example The newer pop and rock music that is being included in each genre, as well as from the Big 6 music corporations, are specifically leading many to have a commercialized expression that will always sell within the genre. The music is becoming a superstructure of what sells, as opposed to providing genuine music. When looking at the different aspects of the top 20, it can be seen that commercialization has taken over the different genres, as opposed to independent artists and variety. The top 20 on itunes included mostly pop and hip hop music, with only one country song and one alternative rock song. The genres continued with the Big 6 having several smaller branches that were sponsoring the artists, as opposed to a larger corporation. However, none of the artists were independent and all were signed to a contact with the Big 6. The same trend was seen at the Last FM site. Most of the artists were in the genre of dance and pop music. The majority of the artists were also signed over to the Big 6 or a branch of the larger corporations. In the Last FM component, there were more rock and alternative sounds with two to three Indie musicians that were mixed in with the others of this genre. However, Last FM also had several of the same artists playing with different songs for a similar affect. Fr om the two areas of Top 20 that were analyzed, several assumptions could be made. The first is that specific genres, such as pop and hip – hop, are the most popular in society on a global level. The second is that the Big 6 are continuing to create a mass response to what individuals are demanding in society. It can also be assumed, from this analysis, that specific musicians are more popular than others and are instantly hitting the Top 20 on a global level, which shows a mass response to cultural icons and artists that are being promoted by

Polycyclic Aromatic Hydrocarbons (PAHs) Research Paper - 3

Polycyclic Aromatic Hydrocarbons (PAHs) - Research Paper Example The truth is there are toxic and non-toxic PAHs occurring naturally in our environment, the non-toxic ones are found in the food we consume (Glenn 1995). They are known as Phytochemicals and are available not only in vegetables but also fruits, grains and several other plants used as foods. These are essential for our health when cooked and consumed appropriately (Sommerburg 1998). This document will discuss the benefits of consuming abundant vegetables in our diet to prevent chronic diseases. Phytochemicals are the bioactive non-nutrient compound found in vegetable. Almost 5000 phytochemicals are estimated to be identified but more are still deemed to be unknown, limiting the full knowledge of the vegetable benefits to our health, suggesting that there could be more benefits. In our day to day activities, our cells are constantly exposed to a lot of oxidizing agents, some toxic and some beneficial to our life. These are the normal PAHs and are found in air, water or the food we consume, some are even being metabolically produced within the cells. Optimal physiologic conditions in our bodies require a balanced state a balanced state of oxidants and antioxidants (Block 1992). Excessive oxidants production causes imbalance which leads to oxidative stress which mostly affects the chronic bacterial, parasitic and even viral infections. This causes serious oxidative damages to the bimolecular substances mainly the proteins, lipids and DNA increasing the risk of chronic disease s like cancer and even cardiovascular disease. Consumption of sufficient antioxidants slows down or even prevents this oxidative stress in our bodies. Vegetables are the known source to have a wide variety of these antioxidant compounds, these may be phenolics or carotenoids which helps in protecting cellular systems from damage due to the oxidative stress, reducing the risk of chronic diseases (Hung 2004). An evidence to show that the compounds found in

Is American dream dead If so should we do anything about it Essay

Is American dream dead If so should we do anything about it - Essay Example However, there are those people who believe that the American dream is dead, while others argue that the American dream is very much alive. Although none is said to be true or false, certain issues happening in the American society contradicts each other. This is the main reason for the divergent views in this motion. Initially, the American dream was concerned about creating opportunities for all Americans, opportunities that did not take into accounts either the race or nationality of people. According to the virtues of the American dream, all Americans deserve equal opportunities before the law. The idea criminalized any form of discrimination against any person due to his colour, race, religion, language, social class or nationality. Every person is entitled to equal opportunities such as job opportunities, enjoyment of rights and enjoyment of people’s freedom. The rate of unemployment in America stands at 7.60 per cent as at June of 2013 while the underemployed rate is at 14.3%. This shows that some of the Americans miss job opportunities due to different reasons. Additionally, people should have an opportunity to share in the national resources and enjoy their privileges. However, this is not the reality on the ground. Most people miss out opportunities due to their colour, race, ethnicity, language and physical looks. Since many people do not have equal opportunities, this has killed the American dream. A number of factors contributing to inequality among the American people are the main reason why the American dream is dead. Inequality, cited as the main pillar of the American dream is highly disregarded. While all Americans are supposed to pay taxes, some enjoy the rare privilege of not paying taxes. Others receive tax deductions that exempt them from paying heavy taxes. Bending of the law through various amendments now allows some people to enjoy more tax reliefs than others. Some even device crooked means of avoiding taxes. Approximately, 46.6 % of Americans do not pay income tax. Moreover, there is a huge wage gap between the rich and the poor people in the society. Approximately16 per cent of the Americans live in poverty, while 20% of the children live in abject poverty. While the rich are entitled to high salaries, the poor are poorly paid. This results in a class difference between the Americans, the rich get richer and the poor remains poorer. Payment of wages need be equal, holding all other factors constant such as level of education, experience, the type of job and the hardships encountered in the work place. Sex should not determine the amount of income that a person should receive. However, in many instances men when compared to women earn higher wages despite the fact that they hold similar positions at work. On the other hand, the American dream is still alive. Despite the cited cases of inequality, the dream is still alive among the Americans. With the high hopes and faith that we have in this dream, various people point out on the need to amend the law to make all people equal. Human rights groups and welfare organizations point out on the need to subject all Americans to a similar tax level. Other humanitarian groups such as the feminists point out that man and women require a similar pay package for similar kinds of tasks handled. Little can however be done about this problem. Despite these cases however, the dream is

Political Science Assignment Example | Topics and Well Written Essays - 250 words - 10

Political Science - Assignment Example Under the Miranda rules, the suspect has a right to contact a lawyer and if he or she cannot afford one, the federal government appoints a lawyer to represent the suspect in court. In addition, the suspect can invoke his or her right to be silent during the interrogation or demand to have an attorney before the interrogation could commence. Americans believe that the police have an obligation to inform the suspect of his or her rights. Indeed, the police read out and confirm that the suspects understand the Miranda rules read to them. The police then enquire from the suspect whether they wish to speak based on their understanding of the Miranda rules (MirandaWarning.Org, 2015). If the suspect does not understand English, the police translate and record the Miranda warning in a language convenient to the suspect. However, the police only give or read the Miranda rights and warnings to a suspect if they are facing interrogation in police custody (Thomson Reuters, 2014). Judges respect the Miranda rules and cannot use any evidence gathered from interrogations that failed to inform the suspect of their Miranda rights and warnings. Even the U.S military provides and requires suspects to sign a form that informs them of their charges and rights that protects them against self-incrimination (MirandaWarning.Org,

Final Paper Essay Example | Topics and Well Written Essays - 3750 words

Final Paper - Essay Example As society processes the information regarding the event, the victims are framed by the news media and public officials. The reaction to the event creates another class of victims as the public is penalized through loss of freedoms and privacy. Innocent people are viewed with suspicion and an unrealistic assessment of the risk places a heavy toll on a stressed society. While terrorism has existed for millennia, recent uses of the criminal act and escalated methods have increased the level of societys awareness of the victims of terrorism. There is a Chinese saying that says, "Kill one [to] frighten ten thousand" (as cited in Ewald, 2006, p.4). Where in centuries past the concept of terrorism was to instill fear, modern terrorism seeks to murder on a massive scale. It is the ability of the terrorists to murder thousands of people in a single event that evokes such fear and dread. Exploring a few of the most significant terrorist acts committed against Americans can help to understand the ways that the victims are viewed and why they become victims. They are generally victims of opportunity and symbolism. Direct victims can be viewed through the positivist lens, while the indirect victims are more aptly analyzed through the anti-positivist viewpoint. The direct victims are real and concrete, while the indirect victims are constructed through societies own labels and judgments. Killing one can indeed frighten ten thousand, and killing 3 thousand can frighten 3 million. Americans have lived with various forms of terrorism since the countrys beginning, but only recently has it been viewed as a complex social issue. Table 1 is a partial list of the most noteworthy terrorist acts in modern history. The 1993 truck bomb at the World Trade Center was the first terrorist event that took place on US soil that attracted large scale public attention. Though there had been a number of airplane hijackings throughout the previous

Instant messaging and Videoconferencing Research Paper

Instant messaging and Videoconferencing - Research Paper Example Another example is when two employees from the same department are working at distance from each other and they have to work in proper collaboration. In such situations, instant messaging is useful as they can send files to them and can talk about them in real time. The benefits of instant messaging include instantaneous response, real time messaging, and file transfer facility. Some other key features of instant messaging include perceived control and telepresence (Zaman, Anandarajan, & Dai, 2010, p. 1009). The challenges related to instant messaging include leakage of trade secrets and privacy issues. Video conferencing helps in communicating being at distance (Judge, 2010, p. 655). It can be useful at workplaces in situations where employees are located at distance from each other and they have to talk to each other frequently to discuss project related issues. Another example is when time is short and manager wants to have a meeting with his/her employees. In such situations, video conferencing is useful because it saves time and increases efficiency and productivity. The benefits of video conferencing include accessibility, utility, and flexibility (Lowden & Hostetter, 2012, p. 377). The challenges related to video conferencing include lack of training to do such interactions and lack of use of nonverbal cues during

Brutus, Antonius, Cassius, and Caesar Essay Example for Free

Brutus, Antonius, Cassius, and Caesar Essay It is 101 BC, the Roman Empire is at its zenith, and a man named Julius Caesar has the power of it within his grasp. Unwanted till now, he soon realizes the influence he now holds over so many lives. Perhaps he is naà ¯ve. However, if choosing who out of Marcus Brutus, Marcus Antonius, Cassius, and Julius Caesar; I choose whom the people chose. Julius Caesar would have been an extraordinary leader of Rome. As a revered general for the empire, he conquered many with an iron fist of trepidity including the dreaded Pompey, whose statue later, in a twisted sense of irony, Caesar meets his untimely fate upon. Caesar was a person the people of Rome could look up to, relate to, and follow. He was born and raised in Rome, joined the army at a young age and showed an almost predilectory understanding of warfare. He rose through the ranks to become the greatest general that Rome had ever known. Caesar was a remarkable man, with many kingly qualities such as his luminosity, endurance, perceptiveness, love for the people, any many, many more. He very well might have been the greatest leader that Rome would even know if not for the inequitable ideas of one man, Cassius. It was only after his return from conquering the mighty Pompey that the glory of Rome became to apparent to Julius Caesar. He wanted the crown; he wanted it like a child wants candy. With his advanced knowledge of subliminal tactics, he devised a plan that would force the citizens to beg him to take the crown. His beloved servant and yes-man, Marcus Antonius, offered him the crown three times with thousands there to witness the event; and each time Caesar refused the crown. Not because he did not want it, for he craved the crown; but because it was part of his brilliant plan. Mark Antonius speaks with anger and passion as he recounts the event of Caesars murder at his funeral, asking the people if Caesars death was truly justifiable: You all did see that on the Lupercal I thrice presented him with a kingly crown, which he did thrice refuse. Was this ambition? III: II: 102-4. At the time the event-which Anotnius gave as evidence that Caesar was not an ambitious  man, which was Brutuss only given reason for partaking in the atrocious manslaughter-Caesar showed such restraint that he had some sort of seizure on stage and was carried away by Antonius and several other men. He showed great power over himself by refusing his craving; a quality that I believe would have made him an excellent leader. Perhaps Antonius did not know of Caesars plan, which is why he spoke so highly of him. Antonius later pleaded with the people of Rome to see the truth, what truth can lie within a dishonest man such as Caesar? A man whom lied in order to persuade the citizens of Rome to make him their king. However dishonest Caesars actions might have been, he showed brilliance and patience on the Lupercal, qualities which are required for a leader, which is quite possibly why the people of Rome chose him over any other men. What ultimately led Caesar to his demise can be construed as either a positive or negative trait when put before one in different contexts. What led him to his death were both his love for Rome, and more importantly his greed. He was a man for the people, believing that he was Gods gift to them; Caesar wanted more then anything to make Rome the greatest Empire the world would ever know, yet he would stop at nothing to accomplish this. His greed would have possibly led the people of Rome into chains, forcing them to work their entire lives in order to better the empire, which is why several members of the Senate felt the need to end his plan before it began. Just after he had killed Caesar, Brutus spoke to the people attempting to explain why he had done what he felt must be done: If then that friend demand why Brutus rose against Caesar, this is my answer: Not that I loved Caesar less, but that I loved Rome more. Had you rather Caesar were living, and die all slaves, than that Caesar were dead, to live all freemen? III: II: 21-5. Brutus was right in the fact that his predictions could have very well come true, but he was wrong in assuming Caesar would not have bettered the empire for the next generation. I believe that Brutus was thinking in the right now sense, instead of tomorrow. Yes, Caesar was ambitious, and yes he was greedy, both of which are necessary qualities for a leader. Many would say that Julius Caesar would have made a horrible leader; that he was naà ¯ve, paltry, inconsiderate, pretentious, and that he had a serious  inadequacy of experience when it came to political affairs. Most would not look further then the fact that he had little experience with politics, and only see his influence to the people as a threat; a very good quality for a man in an authorial position to have, influence. I am almost certain though, that if either Brutus or Cassius had actually sat down and discussed with Caesar what his plans for the future of Rome were, they would have had a serious change of heart and mind. Caesar was a good man who had many ideas as to what an eminent empire requires. His slaughter was untimely and a grievous event which sparked a war within Rome; an event that, ironically, the conspirators had worked so hard to prevent. Caesar would have been an excellent leader of Rome because he not only refrained from making impetuous and misguided deci sions about the other characters, but he displayed selfless loyalty to the citizens of Rome and to those he loved. It is striking and shocking to think what may have happened to the world as we know it if Julius Caesar had lived, lead, and loved.

Sodium, Potassium and Urea Measurement

Sodium, Potassium and Urea Measurement Introduction Electrolytes are solutions that conduct electricity. Any molecule that becomes an ion when mixed with water is an electrolyte. Salts such as sodium, potassium, calcium and chloride are examples of electrolytes. When these molecules dissolve in water, they release ions with an electric charge, positive or negative, that attracts or repels other ions during a chemical reaction. In living cells, most chemical reaction occur in an aqueous environment since approximately 75% of the mass of the living cell is water. Normally 70kg man, represent with 42 litres of total body water that contribute for about 60% of the total body weight. (Marshall, 2000). 66% of this water is in the intracellular fluid (ICF) and 33% in the extracellular fluid (ECF). The principle univalent cations in the ECF and ICF are sodium (Na+) and potassium (K+) respectively. Sodium (Na+) Sodium is the major cation of the extracellular fluid (ECF). It represents almost one-half the osmatic strength of plasma. It plays an important role in maintaining the normal distribution of water and osmatic pressure in the ECF compartment. Sodium levels in the body are regulated ultimately by the kidneys (it excrete excess sodium). The main source of sodium is sodium chloride (NaCl- table salt) which is used in cooking. The daily requirement of the body is about 1 2 mmol/day. Sodium is filtered freely by the glomeruli. About 70 80 % of the filtered sodium load is reabsorbed actively in the proximal tubules (with chloride and water passively) and anther 20 25 % is reabsorbed in the loop of Henle (along with chloride and more water). Normal ECF sodium concentration is 135 145 mmol/L while that of the intracellular fluid (ICF) is only 4-10 mmol/L. sodium is lost via urine, sweat or stool. (Marshall, 2000). Hypernatraemia Hypernatraemia (high sodium levels in the blood) may occurs due to increase sodium intake, decrease excretion, dehydration (water loss) or failure to replace normal water losses. It can also occurs because of excessive mineral corticoid (such as Aldosterone) production acting on renal reabsorption. The clinical features of hypernatraemia are non-specific or masked by underlying conditions. Nausea, vomiting, fever and confusion may occur. A history of long standing polyuria, polydipsia, and theist indicates diabetes insipidus. Hypernatraemia is caused by many diseases such as renal failure, Cushings syndrome or Conns syndrome. Conns syndrome is a disease of the adrenal glands involving excess production of a hormone, called aldosterone. Another name for the condition is primary hyperaldosteronism. Hyponatraemia Hyponatraemia (low sodium levels in the blood) is caused by impaired renal reabsorption of sodium. This occurs in Addisons disease of the adrenal gland due to loss of aldosterone producing zona glomerulosa cortical cells. Sodium decreases in severe sweating in a hot climate or during physical exertion such as marathon running. Falsely low serum sodium concentration may be found in hyperlipidaemic states where the sodium concentration in the aqueous phase of the serum is actually normal, but the lipid contributes to the total volume of serum measured. The symptoms are non-specific and include headache, confusion and restlessness. Hyponatraemia is seen in Addisons disease and/or excessive diuretic therapy. (Kumar Clark, 2002) Potassium (K+) It is the major intracellular cation. It is average concentration in tissue cells is 150mmol/L and in RBCs is 105 mmol/L. The body requirement for K+ is satisfied by a dietary intake. K+ is absorbed by the gastrointestinal tract and distributed rapidly, with a small amount taken up by cells and most excreted by the kidneys. Potassium which filtered by the glomeruli is reabsorbed almost completely in the proximal tubules (PT) and then secreted in the distal tubules (DT) in exchange for sodium under the influence of aldosterone. Factors that regulate distal tubular secretion of potassium include intake of sodium and potassium, water flow rate in distal tubules, plasma level of mineralocorticoids, and acid-base balance. Renal tubular acidosis, as well as metabolic and respiratory acidosis and alkalosis also affect renal regulation of potassium excretion. (Kumar Clark, 2002). Hyperkalaemia Hyperkalaemia is high K+ levels in the blood. Potassium is in high concentration within cells than in extracellular fluids. This means that relatively small changes in plasma concentration can underestimate possibly larger changes in intracellular concentrations. In addition, extensive tissue necrosis can liberate large amounts of potassium into the plasma causing the concentration to reach dangerously high levels. The commonest cause of hyperkalaemia is kidney failure causing decreased urinary potassium excretion. Severe hyperkalaemia (> 6.5 mmol/l) is a serious medical emergency needs treatment as fast as possible because of the risk of developing cardiac arrest. Moderate hyperkalaemia is relatively asymptomatic emphasising the importance of regular biochemical monitoring to avoid sudden fatal complications Hypokalaemia Hypokalaemia (low potassium levels in the blood) has many causes; the most common are diuretic treatment (particularly thiazides), hyperaldosteronism and renal disease. Hypokalaemia is often associated with a metabolic alkalosis due to hydrogen ion shift into the intracellular compartment. Clinically, it presents with paralysis, muscular weakness and cardiac dysrhythmais. (Kumar Clark, 2002) Aldosterone Aldosterone is a steroidal hormone secreted by the adrenal cortex. It is the hormone that regulates the bodys electrolyte balance. This hormone synthesized exclusively in the zona glomerulosa region of the adrenal cortex. This zona contains 18-hydroxysteroid dehydrogenase enzyme which a requisite enzyme for the formation of Aldosterone. Aldosterone acts directly on the kidney tubules to decrease the secretion rate of sodium ion (with accompanying retention of water), and to increase the excretion rate of potassium ion. The secretion of aldosterone is regulated by two mechanisms. First, the concentration of sodium ions secreted may be a factor since increased rates of aldosterone secretion are found when dietary sodium is severely limited. Second, reduced blood flow to the kidney stimulates certain kidney cells to secrete the proteolytic enzyme renin, which converts the inactive angiotensinogen globulin in the blood into angiotensin 1. Another enzyme then converts angiotensin I into a ngiotensin II, its active form. This peptide, in turn, stimulates the secretion of aldosterone by the adrenal cortex. Pathologically elevated aldosterone secretion with concomitant excessive retention of salt and water often results in edema. (Kumar Clark, 2002) Urea is a by-product of protein metabolism that is formed in the liver is formed by the enzymatic deamination of amino acids (urea cycle). The immediate precursor of urea is arginine, which is hydrolyzed to give urea and Ornithine. The urea is excreted by the kidneys and Ornithine in the liver combine with ammonia, formed by the catabolism of amino acids, to regenerate arginine and thereby continue the process of urea formation. The blood urea nitrogen (BUN) test measures the level of urea nitrogen in a sample of the patients blood. In healthy people, most urea nitrogen is filtered out by the kidneys and leaves the body in the urine, because urea contains ammonia, which is toxic to the body. If the patients kidneys are not functioning properly or if the body is using large amounts of protein, the BUN level will rise. If the patient has severe liver disease, the BUN will drop. High levels of BUN may indicate kidney disease or failure; blockage of the urinary tract by a kidney stone or tumour; a heart attack or congestive heart failure; dehydration; fever; shock; or bleeding in the digestive tract. High BUN levels can sometimes occur during late pregnancy or result from eating large amounts of protein-rich foods. A BUN level higher than 100 mg/dl, points to severe kidney damage. (Kumar Clark, 2002) Materials and method Please refer to medical biochemistry practical book (BMS2). Result The equation obtained from the graph used to calculate the Urea concentration of patients is: Y = 0.0238 X Where Y = absorbance X = urea concentration Patient 1 = 0.231/0.0238 = 9.7 mmol/L Patient 2 = 0.149/0.0238 = 6.3 mmol/L Patient 3 = 0.188/0.0238 = 7.89 x 10 = 78.9 mmol/L Patient 4 = 0.376/0.0238 = 7.5 mmol/L Discussion The concentration of sodium and potassium for the four patients was measured by using the flame photometer. For the estimation of urea concentration, a standard calibration curve using different standard concentrations been plotted which used to determine the test samples concentrations. In this practical, the abnormal conditions are varying for each of the patients. Addisons disease is a disorder of the adrenal cortex in which the adrenal glands are under active, resulting in a deficiency of adrenal hormones. Addisons disease can start at any age and affects males and females equally. The adrenal glands are affected by an autoimmune reaction in which the bodys immune system attacks and destroys the adrenal cortex. The glands may also be destroyed by cancer, an infection such as tuberculosis, or another identifiable disease. In infants and children, Addisons disease may be due to a genetic abnormality of the adrenal glands. The majority of the clinical features of adrenal failure are due to lack of glucocorticoid and mineralcorticoid. In Addisons disease cortisol levels are reduced which lead, through feedback, to increase corticotrophin-releasing hormone (CRH) and adrenocorticotrophic hormone (ACTH) production. When the adrenal glands become under active, they tend to produce inadequate amounts of all adrenal hormones. Thus, Addisons disease aff ects the balance of water, sodium, and potassium in the body, as well as the bodys ability to control blood pressure and react to stress. In addition, loss of androgens, such as dehydroepiandrosterone (DHEA), may cause a loss of the body hair in women. A deficiency of aldosterone in particular causes the body to excrete large amount of sodium and potassium, leading to low levels of sodium and high levels of potassium in the blood. The kidneys are not able to concentrate urine, so when a person with Addisons disease drinks too much water or loses too much sodium, the level of sodium in the blood falls. Inability to concentrate urine ultimately causes the person to urinate excessively and become dehydrated. Severe dehydration and low sodium level reduce blood volume and can culminate in shock. Dehydration also causes a high blood urea level. In Addisons disease, the pituitary gland produces more corticotrophin in an attempt to stimulate the adrenal glands. Corticotrophin also stimulat es melanin production, so dark pigmentation of the skin and the lining of the mouth often develop. People with Addisons disease are not able to produce additional corticosteroids when they are stressed. Therefore, they are susceptible to serious symptoms and complications when confronted with illness, extreme fatigue, severe injury, surgery, or possibly severe psychological stress. Secondary adrenal insufficiency is a term given to a disorder that resembles Addisons disease. In this disorder, the adrenal glands are under active because the pituitary gland is not stimulating them, not because the adrenal glands have been destroyed. Blood tests may show low sodium level and high potassium level and usually indicate that the kidneys are not working well. The cortisol level may be low and corticotrophin level may be high. However, the diagnosis is usually confirmed by measuring cortisol level after they have been stimulated with corticotrophin. If cortisol level is low, further tests are needed to determine if problem is Addisons or secondary adrenal insufficiency. Patient-1 has very low sodium 116 mmol/L (135-145 mmol/L), high potassium 6.2 mmol/L (3.6-5.0 mmol/L) and high urea 9.7 mmol/L (3.3-7.5 mmol/L). These abnormal results mostly fit Addisons disease. Sodium been lost in urine in exchange with potassium which causes depletion of Na+ in the blood and increase K+ as both cortisol and aldesterone hormones are absent. Urea level is elevated as a secondary to dehydration and could be due to renal perfusion. ACTH measurement can be used to confirm the diagnosis. Conns syndrome is known as primary aldostronism, is due to the hyper secretion of aldesterone, usually by adenoma of the adrenal cortex or loss often nodular hyperplasia. It characterised by sodium retention and potassium depletion, because plasma renin feed back mechanism is depressed. Under normal conditions aldesterone is regulated by the renin angiotensim mechanism. The principle physiological function of aldesterone is to conserve Na+ . It dose this mainly by facilitating the reabsorption of Na+ and excretion of K+ and H+ in the distal renal tubule. Aldesterone also plays a major role in regulating water and electrolytes balance and blood pressure. The renin-angiotension aldesterone system is the most important controlling mechanism, but ACTH, Na+ and K+ also affect aldesterone secretion. The release of the enzyme renin is stimulated by fall in circulating blood volume or renal perfusion pressure and loss of Na+. The enzyme stimulate the osmoreceptors in the hypothalamus which c auses the release of antidiuretic hormone (ADH) from posterior pituitary gland. ADH targets the kidneys to increase the water reabsorption and causes arterioles to constrict. Renin also acts on its substrate and splits off the inactive decapeptide angiotensim I. Then angiotenism-converting enzyme (ACE), present in lung and plasma, converts angiotensim I to the active angiotensim II which stimulates the release of aldesterone by the adrenal cortex. Aldosterone increases the retention of sodium, chloride ions and water by the kidneys. The laboratory findings include low serum potassium which is a consequence of increased renal potassium excretion, normal or slightly increased sodium in plasma due to increased reabsorption from the renal tubules. Also the renin level will be low and do not rise in response to sodium depletion as they would be in normal persons. In addition, prolonged potassium depletion and hypertension are signs of renal damage. The clinical significance of Coons disease represented with hypertension, muscular weakness and anther neurological manifestation due to loss of K+ which play role in muscles and neurons contraction. Polyuria and thirst secondary to poor renal concentration. Any patient represent hypertension with low potassium concentration should be suspected to have Coons disease. Any patient under diuretic treatment should be monitored overnight as this manifest low potassium. Patient-2 has normal urea level 6.3 mmol/L (3.3-7.5 mmol/L), sodium result is 144 mmol/L, just below the upper limit (135-145 mmol/L) and very low potassium which supports the diagnosis of Coons syndrome. The high aldosterone level in the blood acts on the kidneys to increase the loss of mineral potassium in the urine and facilitate the reabsorption of Na+. Renal failure is the inability of the kidneys to adequately filter metabolic waste products from the blood. Chronic kidney failure is a gradual decline in kidney function which may be explained in terms of a full solute load fall in on a reduced number of functionally normal nephrons. The glomerular filtration rate (GFR) is invariably reduced, associated with retention of urea, creatinine, urate and other organic substances. The kidneys are less able to control the amount and distribution of body water (fluid balance) and the levels of electrolytes (sodium, potassium, calcium, phosphate) in the blood and blood pressure often rise. The kidneys lose their ability to produce sufficient amounts of a hormone (erythropoietin) that stimulates the formation of new red blood cells, resulting in a low red blood cell count (anemia). In children, kidney failure affects the growth of bones. In both children and adults, kidney failure can lead to weaker, abnormal bones. The increased solute load per nephrons impairs the kidneys ability to reduce concentrated urine. As the GFR falls to lower levels retention of Na+ occurs but there is no consistent pattern alteration in plasma Na+ in these cases and in many the results remain normal. Potassium clearance may be increased and raised plasma K+ is uncommon in spite of the tendency for K+ to come out of cells due to the metabolic acidosis that is usually present. However, patients with renal failure are unable to excrete large loads of K+. The level of urea and creatinine will also rise as a result of decreased excretion by the kidneys. Patient-3 has a normal sodium levels 137 mmol/L with a high potassium .8.7 mmol/L and very high urea (78.9 mmol/l) levels which indicates abnormal kidney function. The patient is most probably suffering from chronic renal failure. The numbers of healthy functioning normal nephrons are reduced therefore; there will be a reduction in the execration of urea which will accumulates in the blood. Because of the low GRF, potassium blood levels are increased. The patient must undergo renal dialysis. Diabetic ketoacidosis (DKA) is a common acute complication of insulin-dependent, or type 1 diabetes mellitus (IDDM) due to insulin deficiency which is accompanied by raised plasma concentration of diabetogenic hormones (Adrenaline, Cortisol, Growth hormone and Glucagon ).Before the discovery of insulin in the 1920s, patients rarely survived diabetic ketoacidosis. This complication is still potentially lethal, with an average mortality rate between 5 and 10%. Although the risk of diabetic ketoacidosis is greatest for patients with IDDM, the condition may also occur in patients with non- insulin-dependent diabetes (NIDDM) under stressful conditions, such as during a myocardial infarction. Common symptoms are thirst due to dehydration, polyuria, nausea and weakness that have progressed over several days, which result in coma over the course of several hours. Because of the variable symptoms, diabetic ketoacidosis should be considered in any ill diabetic patient, particularly if the patient presents with nausea and vomiting. Common clinical findings include tachycardia, tachypnea, dehydration, altered mental status and a fruity breath odour, indicating the presence of ketones. Plasma glucose is normally maintained between 4.5 and 8.0mmol/1. Without insulin, most cells cannot use the sugar that is in the blood. Cells still need energy to survive, and they switch to a back-up mechanism to obtain energy. Fat cells begin to break down, producing compounds called ketones. Ketones provide some energy to cells but also make the blood too acidic (ketoacidosis). Since plasma glucose diabetic ketoacidosis exceed the renal threshold; glucose is always present in the urine of patients (glycosuria) with ketoacidosis, the pH of the blood is important in determining the severity of the condition. Blood normally has a pH of 7.35-7.45, maintained by the buffering systems, the most important of which is the bicarbonate buffer system. When acids accumulate in the blood, they dissociate with an increase in hydrogen ion concentration. Bicarbonate can usually neutralise hydrogen ions by incorporating them into water. DKA is associated with electrolyte imbalances; sodium and potassium levels in particular are affected. Serum sodium levels may be low, high or normal. When evaluating the serum sodium level, it is helpful to remember that hyperglycemia causes a shift of free water into the extracellular space, diluting the measured sodium concentration which results in lost of sodium via lie urine as a result of osmotic diuresis. In addition, vomiting, a common feature of ketoacidosis is associated with a loss of sodium from the gastrointestinal tract. This might not always be reflected in the blood results because it is a measure of concentration and, as has already been illustrated, dehydration will be present. Normal plasma sodium levels are maintained between 135 and 145mmol/l, however, despite the actual deficit, patients with DKA might display wide-ranging plasma sodium levels depending on the relative losses of water and sodium. Total body potassium is always depleted in ketoacidosis as potassium is also lost in urine and vomit. The plasma concentration of potassium, however, remains relatively high due to the passage of potassium out of the cells and into the extracellular fluid. One of the mechanisms that normally control the passage of potassium into and out of cells is the sodium/potassium pump. This pump requires intracellular glucose, which is not available in ketoacidosis, consequently, the pump cannot function and potassium leaks out of the cell and into the plasma. Furthermore, potassium is freely exchangeable with hydrogen across the cell membrane. If the hydrogen concentration is high as in DKA, hydrogen will move into the cell in exchange for potassium. So, despite an overall potassium deficit, plasma levels are usually raised in ketoacidosis, at the expense of the body cells. The kidneys can malfunction, resulting in kidney failure that may require dialysis or kidney transplantation. Doctors usu ally check the urine of people with diabetes for abnormally high levels of protein (albumin), which is an early sign of kidney damage. At the earliest sign of kidney complications, the person is often given angiotensin-converting enzyme (ACE) inhibitors, drugs that slow the progression of kidney disease by decreasing blood flow to the kidneys which prevent the kidneys from excreting normal amounts of potassium leads to mild hyperkalaemia. The result obtained for patient-4 corresponding with the clinical findings found in diabetic ketoacidosis. The sodium is reduced (130 mmol/L) and the potassium reading is relatively high (5.8 mmol/L) when compared with the normal reference range. There is a marked increase in urea (15.6 mmol/L) because as mentioned earlier the kidneys can malfunction, resulting in kidney failure that will concentrate fluid in the extracellular compartment. Conclusion Patient 1 is suffering from Addisons disease Patient 2 is suffering from Coons syndrome Patient 3 is suffering from chronic renal failure Patient 4 is suffering from diabetic ketoacidos Questions Calculate the osmolarity (mmol/L) for each patient. Why would patients3s (the diabetic) osmolarity be underestimate? Osmolarity is a property of particles of solute per liter of solution. If a substance can dissociate in solution, it may contribute more than one equivalent to the osmolarity of the solution. The expected osmolarity of plasma can be calculated according to the following formula. Calculated osmolarity (mOsm/kg) = 2*[Na +] + 2*[K+] + (glucose) + (urea) Patient 1 = 2 x 116 + 2 x 6.2 + [glucose] + 9.7 Patient 2 = 2 x 144 + 2 x 2.8 + [glucose] + 6.3 Patient 3 = 2 x 137 + 2 x 8.7 + [glucose] + 78.9 Patient 4 = 2 x 130 + 2 x 5.8 + [glucose] + 15.7 The final result is not obtained as the glucose values are not given, so the calculation can not be done without glucose values. The patient 3 (the diabetic) osmolarity is underestimated because of insulin deficiency, the cells uptake of glucose, which causes hyperglycaemia. What is the abnormality in the clinical condition Diabetes Insipidus, and how does it affect water electrolyte balance? Many different hormones help to control metabolic activities within the body. One of these is called anti-diuretic hormone (ADH) and its function is to help control the balance of water in the body. It does this by regulating the production of urine. ADH is produced by the hypothalamus and then stored in the pituitary gland until it is needed. Diabetes Insipidus usually results from the decreased production of antidiuretic hormone. Alternatively, the disorder may be caused by failure of the pituitary gland to release Antidiuretic hormone into the bloodstream. Other causes of diabetes Insipidus include damage done during surgery on the hypothalamus or pituitary gland; a brain injury, particularly a fracture of the base of the skull; a tumor; sarcoidosis or tuberculosis; an aneurysm (a bulge in the wall of an artery) or blockage in the arteries leading to the brain; some forms of encephalitis or meningitis; and the rare disease Langerhans cell granulomatosis (histiocytosis X). Another type of diabetes Insipidus, nephrogenic diabetes Insipidus, may be caused by abnormalities in the kidneys. Diabetes Insipidus suspected in people who produce large amounts of urine. They first test the urine for sugar to rule out diabetes mellitus. Blood tests show abnormal levels of many electrolytes, including a high level of sodium. The best test is a water deprivation test, in which urine production, blood electrolyte (sodium) levels, and weight are measured regularly for a period of about 12 hours, during which the person is not allowed to drink. A doctor monitors the persons condition throughout the course of the test. At the end of the 12 hours, or sooner if the persons blood pressure falls or heart rate increases or if he loses more than 5% of his body weight, the doctor stops the test and injects Antidiuretic hormone. The diagnosis of central diabetes Insipidus is confirmed if, in response to Antidiuretic hormone, the persons excessive urination stops, the urine becomes mor e concentrated, the blood pressure rises, and the heart beats more normally. The diagnosis of nephrogenic diabetes Insipidus is made if, after the injection, the excessive urination continues, the urine remains dilute, and blood pressure and heart rate do not change. How do diuretics work? And what are the three main groups of diuretics? Diuretics work in the kidneys to increase the elimination of water and electrolytes, thereby causing more urine to form. Because the amount of fluid in the body is lowered, blood pressure goes down, too. Different chemical types work in different areas of the nephrons; so many different classes of diuretics are used. Three of the most common classes of diuretics are: Thiazide and Thiazide-Like Diuretics Drugs containing the chemical Thiazide and similar chemicals like indapamide and metolazone are suggested as the first drugs to try for most people with high blood pressure. They affect the distal convoluted tubule, where large amounts of sodium and water are absorbed back into the body. By blocking the re-absorption process, these drugs force more sodium and more water into the urine to be removed from the body. Thiazides may also relax the muscles in blood vessel walls, making blood flow more easily. Loop Diuretics More powerful than the Thiazide are classes of diuretics that work in the area of the Loop of Henle. These loop diuretics mainly interfere with the bodys re-absorption of chloride, but they also keep sodium from re-entering the blood. Unfortunately, loop diuretics are also more likely to promote the elimination of calcium, magnesium and especially potassium. Shortages of any of these essential electrolytes can cause serious problems such as irregular heartbeats. Potassium-Sparing Diuretics The third common group of diuretics consists of drugs that are much weaker than the Thiazides or the loop diuretics but potassium-sparing diuretics do not reduce potassium levels nearly as much as other kinds of diuretics do. They inhibit aldosterone and/or block sodium reabsorption and inhibit potassium excretion in the distal tubule. Sodium, Potassium and Urea Measurement Sodium, Potassium and Urea Measurement Introduction Electrolytes are solutions that conduct electricity. Any molecule that becomes an ion when mixed with water is an electrolyte. Salts such as sodium, potassium, calcium and chloride are examples of electrolytes. When these molecules dissolve in water, they release ions with an electric charge, positive or negative, that attracts or repels other ions during a chemical reaction. In living cells, most chemical reaction occur in an aqueous environment since approximately 75% of the mass of the living cell is water. Normally 70kg man, represent with 42 litres of total body water that contribute for about 60% of the total body weight. (Marshall, 2000). 66% of this water is in the intracellular fluid (ICF) and 33% in the extracellular fluid (ECF). The principle univalent cations in the ECF and ICF are sodium (Na+) and potassium (K+) respectively. Sodium (Na+) Sodium is the major cation of the extracellular fluid (ECF). It represents almost one-half the osmatic strength of plasma. It plays an important role in maintaining the normal distribution of water and osmatic pressure in the ECF compartment. Sodium levels in the body are regulated ultimately by the kidneys (it excrete excess sodium). The main source of sodium is sodium chloride (NaCl- table salt) which is used in cooking. The daily requirement of the body is about 1 2 mmol/day. Sodium is filtered freely by the glomeruli. About 70 80 % of the filtered sodium load is reabsorbed actively in the proximal tubules (with chloride and water passively) and anther 20 25 % is reabsorbed in the loop of Henle (along with chloride and more water). Normal ECF sodium concentration is 135 145 mmol/L while that of the intracellular fluid (ICF) is only 4-10 mmol/L. sodium is lost via urine, sweat or stool. (Marshall, 2000). Hypernatraemia Hypernatraemia (high sodium levels in the blood) may occurs due to increase sodium intake, decrease excretion, dehydration (water loss) or failure to replace normal water losses. It can also occurs because of excessive mineral corticoid (such as Aldosterone) production acting on renal reabsorption. The clinical features of hypernatraemia are non-specific or masked by underlying conditions. Nausea, vomiting, fever and confusion may occur. A history of long standing polyuria, polydipsia, and theist indicates diabetes insipidus. Hypernatraemia is caused by many diseases such as renal failure, Cushings syndrome or Conns syndrome. Conns syndrome is a disease of the adrenal glands involving excess production of a hormone, called aldosterone. Another name for the condition is primary hyperaldosteronism. Hyponatraemia Hyponatraemia (low sodium levels in the blood) is caused by impaired renal reabsorption of sodium. This occurs in Addisons disease of the adrenal gland due to loss of aldosterone producing zona glomerulosa cortical cells. Sodium decreases in severe sweating in a hot climate or during physical exertion such as marathon running. Falsely low serum sodium concentration may be found in hyperlipidaemic states where the sodium concentration in the aqueous phase of the serum is actually normal, but the lipid contributes to the total volume of serum measured. The symptoms are non-specific and include headache, confusion and restlessness. Hyponatraemia is seen in Addisons disease and/or excessive diuretic therapy. (Kumar Clark, 2002) Potassium (K+) It is the major intracellular cation. It is average concentration in tissue cells is 150mmol/L and in RBCs is 105 mmol/L. The body requirement for K+ is satisfied by a dietary intake. K+ is absorbed by the gastrointestinal tract and distributed rapidly, with a small amount taken up by cells and most excreted by the kidneys. Potassium which filtered by the glomeruli is reabsorbed almost completely in the proximal tubules (PT) and then secreted in the distal tubules (DT) in exchange for sodium under the influence of aldosterone. Factors that regulate distal tubular secretion of potassium include intake of sodium and potassium, water flow rate in distal tubules, plasma level of mineralocorticoids, and acid-base balance. Renal tubular acidosis, as well as metabolic and respiratory acidosis and alkalosis also affect renal regulation of potassium excretion. (Kumar Clark, 2002). Hyperkalaemia Hyperkalaemia is high K+ levels in the blood. Potassium is in high concentration within cells than in extracellular fluids. This means that relatively small changes in plasma concentration can underestimate possibly larger changes in intracellular concentrations. In addition, extensive tissue necrosis can liberate large amounts of potassium into the plasma causing the concentration to reach dangerously high levels. The commonest cause of hyperkalaemia is kidney failure causing decreased urinary potassium excretion. Severe hyperkalaemia (> 6.5 mmol/l) is a serious medical emergency needs treatment as fast as possible because of the risk of developing cardiac arrest. Moderate hyperkalaemia is relatively asymptomatic emphasising the importance of regular biochemical monitoring to avoid sudden fatal complications Hypokalaemia Hypokalaemia (low potassium levels in the blood) has many causes; the most common are diuretic treatment (particularly thiazides), hyperaldosteronism and renal disease. Hypokalaemia is often associated with a metabolic alkalosis due to hydrogen ion shift into the intracellular compartment. Clinically, it presents with paralysis, muscular weakness and cardiac dysrhythmais. (Kumar Clark, 2002) Aldosterone Aldosterone is a steroidal hormone secreted by the adrenal cortex. It is the hormone that regulates the bodys electrolyte balance. This hormone synthesized exclusively in the zona glomerulosa region of the adrenal cortex. This zona contains 18-hydroxysteroid dehydrogenase enzyme which a requisite enzyme for the formation of Aldosterone. Aldosterone acts directly on the kidney tubules to decrease the secretion rate of sodium ion (with accompanying retention of water), and to increase the excretion rate of potassium ion. The secretion of aldosterone is regulated by two mechanisms. First, the concentration of sodium ions secreted may be a factor since increased rates of aldosterone secretion are found when dietary sodium is severely limited. Second, reduced blood flow to the kidney stimulates certain kidney cells to secrete the proteolytic enzyme renin, which converts the inactive angiotensinogen globulin in the blood into angiotensin 1. Another enzyme then converts angiotensin I into a ngiotensin II, its active form. This peptide, in turn, stimulates the secretion of aldosterone by the adrenal cortex. Pathologically elevated aldosterone secretion with concomitant excessive retention of salt and water often results in edema. (Kumar Clark, 2002) Urea is a by-product of protein metabolism that is formed in the liver is formed by the enzymatic deamination of amino acids (urea cycle). The immediate precursor of urea is arginine, which is hydrolyzed to give urea and Ornithine. The urea is excreted by the kidneys and Ornithine in the liver combine with ammonia, formed by the catabolism of amino acids, to regenerate arginine and thereby continue the process of urea formation. The blood urea nitrogen (BUN) test measures the level of urea nitrogen in a sample of the patients blood. In healthy people, most urea nitrogen is filtered out by the kidneys and leaves the body in the urine, because urea contains ammonia, which is toxic to the body. If the patients kidneys are not functioning properly or if the body is using large amounts of protein, the BUN level will rise. If the patient has severe liver disease, the BUN will drop. High levels of BUN may indicate kidney disease or failure; blockage of the urinary tract by a kidney stone or tumour; a heart attack or congestive heart failure; dehydration; fever; shock; or bleeding in the digestive tract. High BUN levels can sometimes occur during late pregnancy or result from eating large amounts of protein-rich foods. A BUN level higher than 100 mg/dl, points to severe kidney damage. (Kumar Clark, 2002) Materials and method Please refer to medical biochemistry practical book (BMS2). Result The equation obtained from the graph used to calculate the Urea concentration of patients is: Y = 0.0238 X Where Y = absorbance X = urea concentration Patient 1 = 0.231/0.0238 = 9.7 mmol/L Patient 2 = 0.149/0.0238 = 6.3 mmol/L Patient 3 = 0.188/0.0238 = 7.89 x 10 = 78.9 mmol/L Patient 4 = 0.376/0.0238 = 7.5 mmol/L Discussion The concentration of sodium and potassium for the four patients was measured by using the flame photometer. For the estimation of urea concentration, a standard calibration curve using different standard concentrations been plotted which used to determine the test samples concentrations. In this practical, the abnormal conditions are varying for each of the patients. Addisons disease is a disorder of the adrenal cortex in which the adrenal glands are under active, resulting in a deficiency of adrenal hormones. Addisons disease can start at any age and affects males and females equally. The adrenal glands are affected by an autoimmune reaction in which the bodys immune system attacks and destroys the adrenal cortex. The glands may also be destroyed by cancer, an infection such as tuberculosis, or another identifiable disease. In infants and children, Addisons disease may be due to a genetic abnormality of the adrenal glands. The majority of the clinical features of adrenal failure are due to lack of glucocorticoid and mineralcorticoid. In Addisons disease cortisol levels are reduced which lead, through feedback, to increase corticotrophin-releasing hormone (CRH) and adrenocorticotrophic hormone (ACTH) production. When the adrenal glands become under active, they tend to produce inadequate amounts of all adrenal hormones. Thus, Addisons disease aff ects the balance of water, sodium, and potassium in the body, as well as the bodys ability to control blood pressure and react to stress. In addition, loss of androgens, such as dehydroepiandrosterone (DHEA), may cause a loss of the body hair in women. A deficiency of aldosterone in particular causes the body to excrete large amount of sodium and potassium, leading to low levels of sodium and high levels of potassium in the blood. The kidneys are not able to concentrate urine, so when a person with Addisons disease drinks too much water or loses too much sodium, the level of sodium in the blood falls. Inability to concentrate urine ultimately causes the person to urinate excessively and become dehydrated. Severe dehydration and low sodium level reduce blood volume and can culminate in shock. Dehydration also causes a high blood urea level. In Addisons disease, the pituitary gland produces more corticotrophin in an attempt to stimulate the adrenal glands. Corticotrophin also stimulat es melanin production, so dark pigmentation of the skin and the lining of the mouth often develop. People with Addisons disease are not able to produce additional corticosteroids when they are stressed. Therefore, they are susceptible to serious symptoms and complications when confronted with illness, extreme fatigue, severe injury, surgery, or possibly severe psychological stress. Secondary adrenal insufficiency is a term given to a disorder that resembles Addisons disease. In this disorder, the adrenal glands are under active because the pituitary gland is not stimulating them, not because the adrenal glands have been destroyed. Blood tests may show low sodium level and high potassium level and usually indicate that the kidneys are not working well. The cortisol level may be low and corticotrophin level may be high. However, the diagnosis is usually confirmed by measuring cortisol level after they have been stimulated with corticotrophin. If cortisol level is low, further tests are needed to determine if problem is Addisons or secondary adrenal insufficiency. Patient-1 has very low sodium 116 mmol/L (135-145 mmol/L), high potassium 6.2 mmol/L (3.6-5.0 mmol/L) and high urea 9.7 mmol/L (3.3-7.5 mmol/L). These abnormal results mostly fit Addisons disease. Sodium been lost in urine in exchange with potassium which causes depletion of Na+ in the blood and increase K+ as both cortisol and aldesterone hormones are absent. Urea level is elevated as a secondary to dehydration and could be due to renal perfusion. ACTH measurement can be used to confirm the diagnosis. Conns syndrome is known as primary aldostronism, is due to the hyper secretion of aldesterone, usually by adenoma of the adrenal cortex or loss often nodular hyperplasia. It characterised by sodium retention and potassium depletion, because plasma renin feed back mechanism is depressed. Under normal conditions aldesterone is regulated by the renin angiotensim mechanism. The principle physiological function of aldesterone is to conserve Na+ . It dose this mainly by facilitating the reabsorption of Na+ and excretion of K+ and H+ in the distal renal tubule. Aldesterone also plays a major role in regulating water and electrolytes balance and blood pressure. The renin-angiotension aldesterone system is the most important controlling mechanism, but ACTH, Na+ and K+ also affect aldesterone secretion. The release of the enzyme renin is stimulated by fall in circulating blood volume or renal perfusion pressure and loss of Na+. The enzyme stimulate the osmoreceptors in the hypothalamus which c auses the release of antidiuretic hormone (ADH) from posterior pituitary gland. ADH targets the kidneys to increase the water reabsorption and causes arterioles to constrict. Renin also acts on its substrate and splits off the inactive decapeptide angiotensim I. Then angiotenism-converting enzyme (ACE), present in lung and plasma, converts angiotensim I to the active angiotensim II which stimulates the release of aldesterone by the adrenal cortex. Aldosterone increases the retention of sodium, chloride ions and water by the kidneys. The laboratory findings include low serum potassium which is a consequence of increased renal potassium excretion, normal or slightly increased sodium in plasma due to increased reabsorption from the renal tubules. Also the renin level will be low and do not rise in response to sodium depletion as they would be in normal persons. In addition, prolonged potassium depletion and hypertension are signs of renal damage. The clinical significance of Coons disease represented with hypertension, muscular weakness and anther neurological manifestation due to loss of K+ which play role in muscles and neurons contraction. Polyuria and thirst secondary to poor renal concentration. Any patient represent hypertension with low potassium concentration should be suspected to have Coons disease. Any patient under diuretic treatment should be monitored overnight as this manifest low potassium. Patient-2 has normal urea level 6.3 mmol/L (3.3-7.5 mmol/L), sodium result is 144 mmol/L, just below the upper limit (135-145 mmol/L) and very low potassium which supports the diagnosis of Coons syndrome. The high aldosterone level in the blood acts on the kidneys to increase the loss of mineral potassium in the urine and facilitate the reabsorption of Na+. Renal failure is the inability of the kidneys to adequately filter metabolic waste products from the blood. Chronic kidney failure is a gradual decline in kidney function which may be explained in terms of a full solute load fall in on a reduced number of functionally normal nephrons. The glomerular filtration rate (GFR) is invariably reduced, associated with retention of urea, creatinine, urate and other organic substances. The kidneys are less able to control the amount and distribution of body water (fluid balance) and the levels of electrolytes (sodium, potassium, calcium, phosphate) in the blood and blood pressure often rise. The kidneys lose their ability to produce sufficient amounts of a hormone (erythropoietin) that stimulates the formation of new red blood cells, resulting in a low red blood cell count (anemia). In children, kidney failure affects the growth of bones. In both children and adults, kidney failure can lead to weaker, abnormal bones. The increased solute load per nephrons impairs the kidneys ability to reduce concentrated urine. As the GFR falls to lower levels retention of Na+ occurs but there is no consistent pattern alteration in plasma Na+ in these cases and in many the results remain normal. Potassium clearance may be increased and raised plasma K+ is uncommon in spite of the tendency for K+ to come out of cells due to the metabolic acidosis that is usually present. However, patients with renal failure are unable to excrete large loads of K+. The level of urea and creatinine will also rise as a result of decreased excretion by the kidneys. Patient-3 has a normal sodium levels 137 mmol/L with a high potassium .8.7 mmol/L and very high urea (78.9 mmol/l) levels which indicates abnormal kidney function. The patient is most probably suffering from chronic renal failure. The numbers of healthy functioning normal nephrons are reduced therefore; there will be a reduction in the execration of urea which will accumulates in the blood. Because of the low GRF, potassium blood levels are increased. The patient must undergo renal dialysis. Diabetic ketoacidosis (DKA) is a common acute complication of insulin-dependent, or type 1 diabetes mellitus (IDDM) due to insulin deficiency which is accompanied by raised plasma concentration of diabetogenic hormones (Adrenaline, Cortisol, Growth hormone and Glucagon ).Before the discovery of insulin in the 1920s, patients rarely survived diabetic ketoacidosis. This complication is still potentially lethal, with an average mortality rate between 5 and 10%. Although the risk of diabetic ketoacidosis is greatest for patients with IDDM, the condition may also occur in patients with non- insulin-dependent diabetes (NIDDM) under stressful conditions, such as during a myocardial infarction. Common symptoms are thirst due to dehydration, polyuria, nausea and weakness that have progressed over several days, which result in coma over the course of several hours. Because of the variable symptoms, diabetic ketoacidosis should be considered in any ill diabetic patient, particularly if the patient presents with nausea and vomiting. Common clinical findings include tachycardia, tachypnea, dehydration, altered mental status and a fruity breath odour, indicating the presence of ketones. Plasma glucose is normally maintained between 4.5 and 8.0mmol/1. Without insulin, most cells cannot use the sugar that is in the blood. Cells still need energy to survive, and they switch to a back-up mechanism to obtain energy. Fat cells begin to break down, producing compounds called ketones. Ketones provide some energy to cells but also make the blood too acidic (ketoacidosis). Since plasma glucose diabetic ketoacidosis exceed the renal threshold; glucose is always present in the urine of patients (glycosuria) with ketoacidosis, the pH of the blood is important in determining the severity of the condition. Blood normally has a pH of 7.35-7.45, maintained by the buffering systems, the most important of which is the bicarbonate buffer system. When acids accumulate in the blood, they dissociate with an increase in hydrogen ion concentration. Bicarbonate can usually neutralise hydrogen ions by incorporating them into water. DKA is associated with electrolyte imbalances; sodium and potassium levels in particular are affected. Serum sodium levels may be low, high or normal. When evaluating the serum sodium level, it is helpful to remember that hyperglycemia causes a shift of free water into the extracellular space, diluting the measured sodium concentration which results in lost of sodium via lie urine as a result of osmotic diuresis. In addition, vomiting, a common feature of ketoacidosis is associated with a loss of sodium from the gastrointestinal tract. This might not always be reflected in the blood results because it is a measure of concentration and, as has already been illustrated, dehydration will be present. Normal plasma sodium levels are maintained between 135 and 145mmol/l, however, despite the actual deficit, patients with DKA might display wide-ranging plasma sodium levels depending on the relative losses of water and sodium. Total body potassium is always depleted in ketoacidosis as potassium is also lost in urine and vomit. The plasma concentration of potassium, however, remains relatively high due to the passage of potassium out of the cells and into the extracellular fluid. One of the mechanisms that normally control the passage of potassium into and out of cells is the sodium/potassium pump. This pump requires intracellular glucose, which is not available in ketoacidosis, consequently, the pump cannot function and potassium leaks out of the cell and into the plasma. Furthermore, potassium is freely exchangeable with hydrogen across the cell membrane. If the hydrogen concentration is high as in DKA, hydrogen will move into the cell in exchange for potassium. So, despite an overall potassium deficit, plasma levels are usually raised in ketoacidosis, at the expense of the body cells. The kidneys can malfunction, resulting in kidney failure that may require dialysis or kidney transplantation. Doctors usu ally check the urine of people with diabetes for abnormally high levels of protein (albumin), which is an early sign of kidney damage. At the earliest sign of kidney complications, the person is often given angiotensin-converting enzyme (ACE) inhibitors, drugs that slow the progression of kidney disease by decreasing blood flow to the kidneys which prevent the kidneys from excreting normal amounts of potassium leads to mild hyperkalaemia. The result obtained for patient-4 corresponding with the clinical findings found in diabetic ketoacidosis. The sodium is reduced (130 mmol/L) and the potassium reading is relatively high (5.8 mmol/L) when compared with the normal reference range. There is a marked increase in urea (15.6 mmol/L) because as mentioned earlier the kidneys can malfunction, resulting in kidney failure that will concentrate fluid in the extracellular compartment. Conclusion Patient 1 is suffering from Addisons disease Patient 2 is suffering from Coons syndrome Patient 3 is suffering from chronic renal failure Patient 4 is suffering from diabetic ketoacidos Questions Calculate the osmolarity (mmol/L) for each patient. Why would patients3s (the diabetic) osmolarity be underestimate? Osmolarity is a property of particles of solute per liter of solution. If a substance can dissociate in solution, it may contribute more than one equivalent to the osmolarity of the solution. The expected osmolarity of plasma can be calculated according to the following formula. Calculated osmolarity (mOsm/kg) = 2*[Na +] + 2*[K+] + (glucose) + (urea) Patient 1 = 2 x 116 + 2 x 6.2 + [glucose] + 9.7 Patient 2 = 2 x 144 + 2 x 2.8 + [glucose] + 6.3 Patient 3 = 2 x 137 + 2 x 8.7 + [glucose] + 78.9 Patient 4 = 2 x 130 + 2 x 5.8 + [glucose] + 15.7 The final result is not obtained as the glucose values are not given, so the calculation can not be done without glucose values. The patient 3 (the diabetic) osmolarity is underestimated because of insulin deficiency, the cells uptake of glucose, which causes hyperglycaemia. What is the abnormality in the clinical condition Diabetes Insipidus, and how does it affect water electrolyte balance? Many different hormones help to control metabolic activities within the body. One of these is called anti-diuretic hormone (ADH) and its function is to help control the balance of water in the body. It does this by regulating the production of urine. ADH is produced by the hypothalamus and then stored in the pituitary gland until it is needed. Diabetes Insipidus usually results from the decreased production of antidiuretic hormone. Alternatively, the disorder may be caused by failure of the pituitary gland to release Antidiuretic hormone into the bloodstream. Other causes of diabetes Insipidus include damage done during surgery on the hypothalamus or pituitary gland; a brain injury, particularly a fracture of the base of the skull; a tumor; sarcoidosis or tuberculosis; an aneurysm (a bulge in the wall of an artery) or blockage in the arteries leading to the brain; some forms of encephalitis or meningitis; and the rare disease Langerhans cell granulomatosis (histiocytosis X). Another type of diabetes Insipidus, nephrogenic diabetes Insipidus, may be caused by abnormalities in the kidneys. Diabetes Insipidus suspected in people who produce large amounts of urine. They first test the urine for sugar to rule out diabetes mellitus. Blood tests show abnormal levels of many electrolytes, including a high level of sodium. The best test is a water deprivation test, in which urine production, blood electrolyte (sodium) levels, and weight are measured regularly for a period of about 12 hours, during which the person is not allowed to drink. A doctor monitors the persons condition throughout the course of the test. At the end of the 12 hours, or sooner if the persons blood pressure falls or heart rate increases or if he loses more than 5% of his body weight, the doctor stops the test and injects Antidiuretic hormone. The diagnosis of central diabetes Insipidus is confirmed if, in response to Antidiuretic hormone, the persons excessive urination stops, the urine becomes mor e concentrated, the blood pressure rises, and the heart beats more normally. The diagnosis of nephrogenic diabetes Insipidus is made if, after the injection, the excessive urination continues, the urine remains dilute, and blood pressure and heart rate do not change. How do diuretics work? And what are the three main groups of diuretics? Diuretics work in the kidneys to increase the elimination of water and electrolytes, thereby causing more urine to form. Because the amount of fluid in the body is lowered, blood pressure goes down, too. Different chemical types work in different areas of the nephrons; so many different classes of diuretics are used. Three of the most common classes of diuretics are: Thiazide and Thiazide-Like Diuretics Drugs containing the chemical Thiazide and similar chemicals like indapamide and metolazone are suggested as the first drugs to try for most people with high blood pressure. They affect the distal convoluted tubule, where large amounts of sodium and water are absorbed back into the body. By blocking the re-absorption process, these drugs force more sodium and more water into the urine to be removed from the body. Thiazides may also relax the muscles in blood vessel walls, making blood flow more easily. Loop Diuretics More powerful than the Thiazide are classes of diuretics that work in the area of the Loop of Henle. These loop diuretics mainly interfere with the bodys re-absorption of chloride, but they also keep sodium from re-entering the blood. Unfortunately, loop diuretics are also more likely to promote the elimination of calcium, magnesium and especially potassium. Shortages of any of these essential electrolytes can cause serious problems such as irregular heartbeats. Potassium-Sparing Diuretics The third common group of diuretics consists of drugs that are much weaker than the Thiazides or the loop diuretics but potassium-sparing diuretics do not reduce potassium levels nearly as much as other kinds of diuretics do. They inhibit aldosterone and/or block sodium reabsorption and inhibit potassium excretion in the distal tubule.

The Variations in Little Red Riding Hood Essay -- Fairy Tales Literatu

The Variations in Little Red Riding Hood Fairy tales are under attack in the United States from both right- and left-oriented pressure groups. (Ravitch, 62-96) From the left, the charges include sexism, stereotyping, distortion, and anti-humanism. (Ravitch, 84) From the right, the charges include immorality and objections to the portrayal of violence, death, and the supernatural. In addition, some critics claim that the tales terrify their children. (Ravitch, 76). In The Language Police, Diane Ravitch claims that both groups understand the importance of putting pressure on state textbook adoption committees, and that, as a result of such pressure, most major publishers are simply dropping the tales from the textbooks they sell to schools. (77-78) Thus parents who assume, or would prefer that, their children are reading traditional fairy tales in school may find themselves mistaken. The seriousness of the question is itself a matter of debate, but the biggest problem with the current debate is that a fairy tale is assumed to be a fairy tale in the sense that Dickens's A Tale of Two Cities is A Tale of Two Cities. Editors do make some changes in Dickens's text, but essentially what Dickens wrote is what he wrote. This is not the case, however, with fairy tales. There are several, perhaps dozens, of different versions of most of the best-know tales. To argue that tale "A" is good or bad, moral or immoral, for children to read is thus comparable to building a house out of straw. One of the central tales in the debate is "Little Red Riding Hood," and Little Red Riding Hood" is assumed to be Little Red Riding Hood. It isn't. There are apparently dozens of versions of this tale, but the best known are those by Charles Perra... .... 28, 2002. ProQuest Direct. Penn. Coll. Lib., Williamsport. 22 August 2004. <http://www.proquest.umi.com/pdqweb>. Ravitch, Diane. The Language Police: How Pressure Groups Restrict What Students Learn. N.Y.: Alfred A. Knopf, 2003. Tatar, Maria. Off with their Heads! Fairy Tales and the Culture of Childhood. Princeton: Princeton University Press, 1992. Weldon-Lasiter, Cynthia. Review of Little Red Riding Hood: A Newfangled Fairy Tale. Book Links. 11:4 (Feb/Mar, 2002):11. . ProQuest Direct. Penn. Coll. Kib., Williamsport. 22 August 2004. <http://www.proquest.umi.com/pdqweb>. Ziolkowski, Jan. M. "A Fairy Tale from before Fairy Tales: Egbert of Liege's 'De puella a lupellis seruata' and the Medieval Background of 'Little Red Riding Hood'." Speculum 67:3 (July 1992): 549-575. JSTOR. Penn. Coll. Kib., Williamsport. 23 July 2004. <http://www.jstor.org>.

Evolution vs.Creationism Essay -- essays research papers

Evolution Vs Creationism People have always wondered how life originated and how so many different kinds of plants and animals arose. Stories of a supernatural creation of life developed among many peoples. The Bible, for example, tells of God's creation of humans and other higher animals over several days. Many people also believed that insects, worms, and other lower creatures spontaneously generated from mud and decay. Long after these stories became rooted in tradition, scientists began to question them. Albert Einstein said, "The scientist's religious feeling takes the form of a rapturous amazement at the harmony of natural law, which reveals an intelligence of such superiority that, compared with it, all the systematic thinking and acting of human beings is an utterly insignificant reflection." (Creation 9). The first serious attack on the idea of spontaneous generation of life was made in 1668 by Francesco Redi, an Italian physician, who proved that maggots did not arise spontaneously in decaying matter, as commonly believed, but from eggs deposited there by flies. Proof that microorganisms are not generated spontaneously came in the 1860s, when Louis Pasteur, a French scientist, showed that they, too, develop from preexisting life. Evolution can be defined in many ways. One of the most respected evolutionary biologists has defined biological evolution as follows: "In the broadest sense, evolution is merely change, and so is all-pervasive; galaxies, languages, and political systems all evolve. Biological evolution ... is change in the properties of populations of organisms that transcend the lifetime of a single individual. The ontogeny of an individual is not considered evolution; individual organisms do not evolve. The changes in populations that are considered evolutionary are those that are inheritable via the genetic material from one generation to the next. Biological evolution may be slight or substantial; it embraces everything from slight changes in the proportion of different alleles within a population (such as those determining blood types) to the successive alterations that led from the earliest protoorganism to snails, bees, giraffes, and dandelions." (Futuyma, 11) Exactly how evolution occurs is still debated but it is a scientific fact that it does occur. Most biologists believe that... ...nism vs. Evolution rages in the American popular culture. The tension between how people interpret the Bible and what people believe that they have learned through science has been with us for a long time. The fact is science and the Bible is both needed to find the truth. This complex topic presents many issues such as faith, scientific reasoning, and personal beliefs. This generation would probably be more inclined to believe in evolution rather than creationism, merely because today's educational system does not teach creationism as much as evolution. We are taught that science answers everything. Personally after researching the theory of evolution it is more real and not so fictional and fairy-tale like as creationism. Work Cited (Britannica) McHenry, Robert ed. The New Encyclopedia Britannica. Delusion-Frenssen. 15th ed. Chicago: University of Chicago, 1992. (Creation 9.) No Answers In Genesis. http://www.onthenet.com.au/~stear/. Darwin, Charles The Origin Of Species (Darwin) McHenry, Robert ed. The New Encyclopedia Britannica. Ceara-Deluc. 15th Edition. Chicago: University of Chicago, 1992. (Douglas J. Futuyma.) The World As I See It. New York: Watts & Co, 1975

Gender And Relationship Of Children :: essays research papers

Gender and Relationship of Children Introduction   Ã‚  Ã‚  Ã‚  Ã‚  The topic of sex differences in the play preschoolers has been explored by many researchers in the past. Studies have been conducted on basic sex differences such as what toys and gender of playmates do young boys and girls prefer. The size of children's play networks, as well as if these networks change in the size during the preschool years have been explored. Also, differences in styles of play and the occurrence of positive and negative interactions have been examined. The effect that parents have on their sons and daughters, as well as preschool classrooms and teachers have been examined as possible causes of sex differences during play.   Ã‚  Ã‚  Ã‚  Ã‚  The aim of this paper is to critically review the recent literature in this field and determine whether or not sex differences occur in play. If sex differences occur, the possible reasons for this occurrence will also be examined. Review of the Research Section   Ã‚  Ã‚  Ã‚  Ã‚  Maccoby (1990) summarized a number of studies to support her hypothesis that suggests different social situations may either heighten or suppress sex differences in behaviour.   Ã‚  Ã‚  Ã‚  Ã‚  One study was that of social interaction between pairs of young children (Jacklin & Maccoby, 1978). Pairs of 33-month old children were brought together in the same-sex or mixed-sex in a laboratory playroom, and the amount and kind of social behaviour directed more social behaviour, both positive and negative, to same sex playmates that opposite sex ones. Girls paired with boys were more likely to stand watching their partners, or withdraw towards an adult, than boys in any pairing or girls playing with girls. The point brought up in this study is that interactive behaviour is not just situationly specific, it also depends on the gender of participants.   Ã‚  Ã‚  Ã‚  Ã‚  Some of the reasons given by Maccoby (1990) for attraction to same sex partners and avoidance of other sex partners in childhood are the rough play style of boys and their orientation towards competition and dominance. Another reason is that girls find it difficult to influence boys. An example of such reasoning is supported by a study done by Poulishta (1987). Preschool aged boy- girl pairs were observed competing for an object. The children were given a chance to use a movie-viewer that could only be used by one child at a time. It seemed while pairs were alone in the playroom the boys dominated the movie- viewer. When an adult was present, however, this did not occur, The adult's presence seemed to inhibit the boy's more power assertive techniques resulting in equal access. This supports the reason why the attraction to same sex

Ethical Issues in India Essay

For Subject Business Ethics & Corporate Governance 2G Spectrum Scam We have had a number of scams in India; but none bigger than the scam involving the process of allocating unified access service licenses. †¢It is Rs.1.76-lakh crore worth of scam. The amount is approximately 2% of national GDP or 1/3 of current tax revenue of India. It is also equals to annual income of telecom service sector. †¢The former Telecom minister A Raja who according to the CAG, has evaded norms at every level as he carried out the dubious 2G license awards in 2008 at a throw-away price which were pegged at 2001 prices. Beneficiaries: Reliance Communication allegedly had stake 10.7% of in swan telecom.But according to rule a telecom operator cannot own more than 10% stake in another telecom operator company operating  in  same  area. Unitech had no experience in telecom sector but according to rule the license should be given to those who have experience in telecom sector. They got license for throw away price of Rs. 1661 crore. It sold its 60% stake to Telenor at Rs. 6200 crore. Swan Telecom got license for Rs. 1500 Crore.it sold 45% stake to UAE based Etisalat at Rs. 9800  crore. Swan  Telecom  had  no  experience  in  telecom  sector. Other beneficiaries include Datcom solution, Loop Telecom, Tata teleservice, STel ltd, Idea cellular & spice communication. Ethical issues: With outbreak of 2G scam following ethical issues on the part of Government, Regulatory bodies, Media & industry came into forefront. Governance: Spirit of collective responsibility not conserved.  Seemed like throwback to the license raj era. Regulation: Toothless with only advisory powers. Insufficient manpower worsens the situation  Appointment process aid conflict of interests  Proper decentralization of powers & implementation of existing rules may have prevented this scam. Media should understand its responsibility towards people of India. Adequate power & resources should make available to regulatory bodies. Common Wealth Games Fraud The Delhi Common Wealth Games (CWG) investigations by Central Vigilance Commission (CVC) revealed irregularities and fraudulent practices adopted by the organization committee members.  The estimated figure for misappropriation of funds is Rs 8000 crore (Rs 80,000 million). The investigations have recently commenced and the problems reported are as follows. †¢ Purchase contracts signed with varying rates for the same product †¢Prices over-inflated in some contracts †¢Contracts given to relatives and friends †¢Sub-standard products purchased †¢Vendor payments made without confirming quality and delivery †¢Payments made to non-existent vendors The organization committee members ignored the Prevention of Corruption Act and government procedures for contracts and tenders. Ethical issues: From the perspective of purchasing process, the following ethical issues are apparent: †¢ Improper and inadequate vendor selection and evaluation procedures were followed. †¢Conflict of interest was not disclosed while signing contracts with related parties. †¢Tenders were not given to bidders quoting lowest price of the product. †¢Vendors did not deliver the contracted quality and quantity as per the delivery schedule. †¢Vendors were not penalized for sub-standard quality or late delivery. †¢Vendor payments were not linked to delivery of products or completion of deliverables. †¢There was no segregation of duties. The same officials authorized the contract and approved payments. An independent evaluation of contracts by risk managers may have prevented misappropriation of funds. A periodic audit by government agencies could have highlighted these issues at an earlier stage. As Comptroller and Auditor General (CAG) group is required to conduct periodic audits of all government expenses, it is surprising that these issues were not discovered earlier. This clearly indicates miss-utilization of public funds. Adarsh Scam A tall building is built in Colaba area of mumbai just adjacent to lands of Indian navy, now as per navy this building is security threat for its assets and as per law it is illegal to build such structures near defence land. Now another issue is that the land on which the Adarasha society ( building) has been built is allocated for relocation of families of Kargil war Martyrs. but thing happened is that the society was granted permission under name of Kargil war heroes and most of the flats were allocated to relatives of maharashtra ministers Now from looking to a facts it gives impression that biggest culprits in this scam are ministers of maharashtra who sanctioned the permission, bureaucrats who had sufficient money to purchase flats in the society on the name of their relatives, So overall looking scam is result of joint Venture of bureaucracy and politicians of Maharashtra. Ethical issues: †¢Why objection is taken after completion of building and not during the building was being built? †¢Power to give land at discounted rate should be more transparent. Government should bring more transparency in process of giving land at discounted rate. They should monitor whether housing societies or organizations are following rule applicable to them. ‘Adarsh scam’ in Pune Details of another land scam have surfaced from Pune in which high ranking army, police, civil, transport and urban land department officials had joined to grab houses in what was meant to be a defense society. Documents in possession of TIMES NOW prove that Defense Personnel Housing Society (DPCHS), which was supposed to house Kargil war widows, has illegally been sold off to bureaucrats. The list of allottees in this society also includes the personal secretaries of former Maharashtra Chief Minister Vilasrao Deshmukh and Narayan Rane. The DPCHS, which was formed by defense personnel, had applied to the district collector for allotment of land for a housing society in 2003. In response, the government had allotted 1.86 hectares in Lohegaon. In 2003 the society was alloted the land which was meant for Kargil war widows. However, in 2010 the society filed a fresh list of allottees 100 of which included bureaucrats. The Pune collector has cracked down on the society and ordered an inquiry into the irregularities. Ethical issues: †¢The DPCHS was fromed for defense personnel. At present it has 200 members. Nearly 50 per cent of the members are employees at various government departments. †¢Power to give land at discounted rate should be more transparent. Government should bring more transparency in process of giving land at discounted rate. They should monitor whether housing societies or organizations are following rule applicable to them. The loan scam The economic offences wing of the Central Bureau of Investigation on unearthed a major fake housing loan racket and arrested eight officials from various banks on graft charges. CBI arrested CEO of LIC Housing Finance Ramachandran Nair and seven others senior bankers in connection with a housing finance racket. Apart from Nair, those arrested are Naresh K Chopra, Secretary (Investment), LIC, R N Tayal, General Manager of Bank of India (Delhi), Maninder Singh Johar, Director (Chartered Accountant) of Central Bank of India, Venkoba Gujjal and Dy General Manager of Punjab National Bank (Delhi). Rajesh Sharma, CMD of Mumbai based firm Money Matters Ltd and two of its employees Suresh Gattani and Sanjay Sharma were among those arrested. The bank officials allegedly colluded with the firm to sanction large scale corporate loans, overriding mandatory conditions for such approvals along with other irregularities. The Finance Ministry said it would explore the possibility of instituting a departmental inquiry into the housing finance racket that led to arrest of senior officials of the LIC Housing Finance and public sector banks. The CBI has alleged that Naresh Chopra, secretary (investment) LIC, had assured Rajesh Sharma of Money Matters that he would â€Å"disfavour the proposal of DB Realty, which had approached it for a loan through some other agent.† Subsequently , DB Realty approached Money Matters and got a loan worth Rs 200 crore sanctioned and disbursed within four months. Ethical issues: †¢Role of intermediaries such as money matters is suspicious in entire scam. †¢Too much power in the hands of a very few. There should be greater transparency in giving loan by financial institutes. there is need to destroy such rackets in financial institutes & banks. Air India charged double fare to rescue Indians in Egypt. The 320 Indians who were evacuated on the special Air India (AI) flight had to pay more than double the cost of a single ticket from Cairo to Mumbai. A one-way ticket in this sector averages at Rs 17,000-20,000, but stranded travelers said they had to pay Rs 45,000 before they were assured of a seat on the AI 160 flight to Mumbai. For a few people, the fare was as high as Rs 55,000. Tourists and honeymooners, many of whom were on a budget and did not have access to immediate funds, were the worst hit. Many fliers complained that they had to pay cash on the spot to be able to procure a flight ticket. AI flight was a boon because our earlier flight had been cancelled. But they had to pay double money on the spot to get on the plane. At the end of a holiday, most people do not have so much cash in hand. Ethical issues: †¢AI took undue advantage of Emergency situation. †¢Air India should understand the responsibility towards Indians. There should be transparency in fare of airlines especially during time of emergency. Rs.300 Crore Citibank Fraud Mr. Shivraj Puri, an employee of Gurgoan branch had siphoned of money from 40 high networth investors (HNI) amounting to Rs 400 crore. Mr. Shivraj Puri is a Senior Relationship Manager in Citibank Gurgoan branch. He used a forged notification of Securities & Exchange Board of India (SEBI) stating that few select clients would earn higher returns (18% to 20%) if they invested in his suggested schemes. He invested the money obtained from HNI in the stock market in his personal capacity over a period of few months. He invested money in share market through brokage firms Religare and Bonanza the main client affected by the fraud is Hero Honda group and the amount diverted is to the tune of Rs 200 crore (USD 44.67 million).  Mr. Sanjay Gupta, Assistant Vice President in the accounts office of Hero Corporate Services have formed two finance companies BG Finance and G2S Consultancy and diverted Hero group promoter funds in these two companies. These funds were then fraudulently invested by Mr. Shivraj Puri of Citibank. Mr. Sanjay Gupta has allegedly taken Rs 20 crore (USD 4.46 million) as commission from Mr. Shivraj Puri for diverting these funds. It is suspected that Mr. Sanjay Gupta was aware of the forged SEBI letter but recommended the investment to a number of people. Ethical issues: †¢Lack of control and supervision on the activities of the Relationship Manager. †¢Religare and Bonanza should have questioned the source of funds of Mr. Puri as he is a salaried employee. †¢The fraud department was alerted by the customer complaints. This raises questions on fraud detection and monitoring procedures implemented at the bank. Banks & financial institutes should monitor suspicious transactions with special emphasis on HNI accounts. There should be adequate control over relationship managers activities. India’s latest rice scam involves Rs 200,000 crore The latest of the scam series in India, the UP rice scam could be the biggest of them all, even outdistancing the so called 2G Spectrum scam. According to reports, a huge stock of food grain meant for distribution under the Antyodaya, Annapurna and Mid-Day Meal schemes was smuggled outside the state and even the country to Bangladesh, Nepal and other nations. It is believed that top officials of the state as well as the central government colluded to divert the food grain between 2001 and 2007. The scam involves goofing up of rice worth Rs 200,000 crore. It was a scam that stretched to almost 7 years and 300 FIRs. The scam was reported in Uttar Pradesh in the period when Samajwadi Party leader Mulayam Singh Yadev was the chief minister of the UP. This food grain was for poor people either free or at highly subsidies rate. Ethical issues: Food grains meant for poor had been smuggled into the open market and also into the neighboring countries and none of that could have happened without the involvement of higher authorities. Transportation by goods trains to far off corners of the country indicated that smuggling happened in collusion with different authorities. No action was taken in last 10 years. Distribution system of food grain for poor people should be more transparent. it should be more accountable. It is necessary to break such rackets in public distribution system to avoid national loss. Proper use of technology such as GPS tracker, RFID tag can make distribution more efficient. There is need for frequent checks.